Cosa producono le natural killer?

Cosa producono le natural killer?

Servono a contenere le infezioni virali mentre la risposta immunitaria adattativa genera cellule T citotossiche antigene-specifiche che possono eliminare l'infezione. Le cellule NK lavorano per controllare le infezioni virali secernendo IFNγ e TNFα.

Quanto vivono i linfociti?

Al contrario dei linfociti B, la cui vita media è di pochi giorni (fatta eccezione per le "cellule della memoria"), i linfociti T sopravvivono per diversi mesi o anni. Sono responsabili dell'immunità cellulo mediata (attiva contro i patogeni intracellulari, come i virus ed alcuni batteri).

Quando si attivano i linfociti T?

I linfociti T vengono attivati dall'interazione con il complesso maggiore di istocompatibilità (MHC) che trasporta l'antigene.

What is a car-NK cell?

• Abstract NK cells can be derived from various sources (PB, UCB, HSC, iPSC, NK cell lines) and can be engineered to express a chimeric antigen receptor (CAR) to target various surface antigens on cancer cells. These CAR‐NK cells can be used as off‐the‐shelf adoptive cellular therapy to treat patients with various malignancies.

What is the source of NK cells?

• NK cells can be derived from various sources (PB, UCB, HSC, iPSC, NK cell lines) and can be engineered to express a chimeric antigen receptor (CAR) to target various surface antigens on cancer cells. These CAR‐NK cells can be used as off‐the‐shelf adoptive cellular therapy to treat patients with various malignancies.

What switches on and off the NK cells?

• cells, and ‘switch on’ the NK cell. Inhibitory receptors act as a check on NK cell killing. Most normal healthy cells express MHC I receptors which mark these cells as ‘self’. Inhibitory receptors on the surface of the NK cell recognise cognate MHC I, and this ‘switches off’ the NK cell, preventing it from killing.

What is the role of NK cells in pregnancy?

• As well as protecting against disease, specialized NK cells are also found in the placenta and may play an important role in pregnancy. NK cells were first noticed for their ability to kill tumour cells without any priming or prior activation (in contrast to cytotoxic T cells, which need priming by antigen presenting cells).